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HELIXPAN

Solid Tumor Interception

HELIXPAN is a prevention program aimed at evaluating the prodromal phase of solid tumors, except for those of the brain.

HELIXPAN provides a molecular assessment of genomic stability by detecting somatic mutations that may signal the earliest steps of tumor development. Its value lies not only in the identification of these alterations at a given moment, but above all in the possibility of tracking their evolution over time.

The strength of the HELIXPAN protocol is the annual repetition of the test, which enables longitudinal monitoring of emerging or changing mutations. This continuous surveillance offers clinicians a dynamic view of the patient’s genomic profile, supporting early detection strategies and personalized preventive interventions based on real-time molecular evidence.

Indications

The HELIXPAN test is recommended for individuals who wish to proactively monitor their long-term health by assessing early genomic alterations associated with the development of solid tumors. It is particularly suitable for people who:

  • lead a generally healthy lifestyle and follow balanced dietary and behavioral habits;

  • are not exposed to significant environmental or occupational pollution;

  • have no symptoms or medical history that would require a disease-specific surveillance program;

  • wish to complement routine medical check-ups with a genomic approach capable of detecting early signs of somatic instability;

  • are interested in a preventive strategy based on the annual monitoring of somatic mutations to support early detection and personalized risk assessment.

HELIXPAN is ideal for those who aim to maintain control over their genomic health, even in the absence of known risk factors, by adding a cutting-edge molecular tool to their preventive routine.

What the test evaluates

The HELIXPAN test can detect genetic instability (or genomic instability), evaluated by monitoring the frequency of somatic mutations, the main indicator of the prodromal phase of solid tumors.

50 genes, 2800 mutations
ABL1ALKATMJAK3CSF1R
EGFRERBB4FBXW7NRASFLT3
GNASHNF1AIDH1SRCKDR
KRASMLH1BRAFCDKN2APIK3CA
PTPN11RETFGFR1FGFR3TP53
AKT1APCJAK2IDH2CTNNB1
ERBB2EZH2NPM1PDGFRAGNA11
GNAQHRASSMOSTK11KIT
METMPLCDH1NOTCH1PTEN
RB1SMAD4FGFR2SMARCB1VHL

An innovative model

HELIXPAN represents a modern approach to cancer prevention, based on the objective evaluation of somatic mutations rather than on subjective or family-based risk assessments. Through liquid biopsy and Next Generation Sequencing (NGS), the test identifies and quantifies acquired mutations that may reflect early genomic instability—one of the earliest measurable indicators associated with the development of solid tumors.

Its true strength lies in the ability to repeat the analysis annually, allowing the monitoring of mutation frequencies over time. By comparing results year after year, HELIXPAN provides a dynamic view of the patient’s genomic stability, enabling the early detection of emerging alterations and supporting a more precise and personalized preventive strategy.

How the test is performed

Bioscience Institute offers pre-test advice and provides all useful information about the prevention program and the execution of the HELIXPAN test.

The test involves a simple blood sample that can be performed at one of our reference centers or through your doctor.

The Bioscience Institute laboratories extract the DNA present in the sample and sequence it using the advanced Next Generation Sequencing (NGS) techniques. The subsequent bioinformatics analysis allows the determination of the presence of any mutations in the genes under examination.

Test results are available in approximately 30 days.

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